"Trump vs Oprah would be the most epic race in American history. MAKE THIS HAPPEN..." Drudge, the founder of the conservative Drudge Report, wrote in a tweet to his nearly 500,000 followers.
According to The Hill, The "Queen of All Media" had suggested that Trump made her rethink whether she could win a presidential race.
"Have you ever thought that, given the popularity you have — we haven’t broken the glass ceiling yet for women — that you could actually run for president and actually be elected?" Bloomberg Media's David Rubenstein asked Oprah in an interview.
Winfrey paused before answering, prompting laughter from the audience.
Winfrey said during an appearance on "The Late Show with Stephen Colbert" in January that she would never run for president.
“Is there any other charismatic African-American woman that both sides of the political aisle really love?” Colbert asked after a reference to Michelle Obama, prompting applause from the show's audience.
“Never,” Winfrey said. “No, no, it’s not my thing.”
Meanwhile, Trump has in years past floated Oprah as his own potential running mate, saying in 2015, "I think we'd win easily."