The musician announced Friday his next tour will be his last and opened up for the first time about his condition in an interview with "CBS This Morning: Saturday" co-host Anthony Mason.
Frampton said he has been furiously recording music since he was diagnosed with inclusion body myositis, a rare and incurable inflammatory condition which causes muscles to weaken slowly.
"Between October and two days ago, we've done like 33 new tracks," he said. "I just want to record as much as I can, you know, now, for obvious reasons."
"Going upstairs and downstairs is the hardest thing for me," he said. "I'm going to have to get a cane ... and then the other thing I noticed, I can't put things up over my head."
Frampton was diagnosed about three and a half years ago after a fall on stage. The disease progressed gradually, but sometime around last September or October, after he came off tour, he felt the effects speed up. He started to make plans to leave the road after a particularly bad fall while on vacation with his daughter in Maui.
"What will happen, unfortunately, is that it affects the finger flexors," he said. "That's the first telltale sign is the flexors, you know. So for a guitar player, it's not very good."
His run started in the 1960s, as a teen idol in England with the group, The Herd. Frampton then co-founded Humble Pie, a band that took him onto the British charts.
But his breakthrough would come as a solo artist with his live album "Frampton Comes Alive," which spent 10 weeks at No. 1.
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